- April 25, 2016
- Posted by: emobile
- Category: Uncategorized
Emobileclinic Trending Topic: Spermatogenesis
Spermatogeneis is the process of sperm production and involves several steps that lead to the differentiation of cells into functioning sperm cells. The process occurs in the seminiferous tubules of the testes. Sperm should be differentiated from the semen which is ejaculated with sexual intercourse. Semen is composed of sperm with fluid from the vas deferens, seminal vesicles, prostate gland, and other accessory glands.
Sperm Production in the Testes
It is a multi-step process that occurs within the seminiferous tubules which are long hollow coiled tubes in the testes. There are close to 1,000 such tubules measuring some one and a half meters in each testis. The sperm cells accumulate in the lumen of the seminiferous tubules and pass out through the epididymis where it matures further before passing out along with other glandular secretions as semen.
The entire process of spermatogenesis is mainly driven by hormones. Follicle stimulating hormone (FSH) plays an integral role in the development of testicular tissue for the process of sperm production. Luteinizing hormone (LH), stimulates the Leydig cells of the testes to secrete testosterone. Both FSH and LH secretion by the pituitary gland is regulated by gonadotropic-releasing hormone (GnRH) released by the hypothalamus.
Testosterone is essential for the maturation of cells and both starts and regulates the entire sperm production process. Growth hormone (GH) ensures that the testicular cells are constantly growing and active to meet with the metabolic demands of spermatogenesis. Small amounts of estrogen in males derived from testosterone may also play some role in the final differentiation of spermatids into fully functioning spermatozoa.
Manufacture of Sperm
There are four major types of cells that arise during spermatogenesis:
2. Spermatocytes – primary and secondary
In the male fetus, the primordial germ cell enters the testis and becomes immature germs cells known as spermatogonia . These cells divide by mitosis to form more spermatogonia. Each cell beigins to differentiate to form the primary spermatocyte, at this point, the primary spermatocyte undergoes meiotic division (meiosis) to form secondary spermatocytes. These cells then undergo meiotic division again to form two spermatids, each with half of the number of chromosomes of the secondary spermatocytes.
Therefore each spermatid has only 23 chromosomes compared to the 46 chromosomes (23 pairs) in the secondary spermatocytes. The spermatids then differentiate further to form spermatozoa (sperm cells) and this part of the process is known as as spermiogenesis.
Life span and quantity of Sperm
This entire process takes approximately 74 days and the two testes produces about 120 million sperm per day. Sperm that exit the seminiferous tubules are fully developed but immobile. It takes about another day for it to mature further and become motile within the epididymis. This maturation is a result of testosterone, estrogen, enzymes and nutrient-rich fluid secreted by the Sertoli cells and lining of the epididymis. Sperm in the epididymis and vas deferens can be stored for about a month but is inhibited by local factors which keeps it inactive.
Parts of the Sperm
The two main parts of the sperm is the head and tail.
The head has a thickened front part known as the acrosome. It contains strong enzymes to digest tissue and allow the sperm to enter the ovum (egg in females) and fertilize it. The rest of the head is essentially a cell like any other cell but being a sex cell, it contains only half the number of chromosomes as other non-sex cells.
The tail has a thickened portion known as the tail body attached to the head by the neck. The body of the tail is laden with mitochondria which provides for the high energy demands of the sperm cell when moving. The tail, also known as the
flagellum, has a number of microtubules collectively called the axoneme which is located in the center of the tail. The axoneme is the main mechanism that powers the movement of sperm.
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