”some serious side effects have occurred during the use of bromocriptine to stop milk flow after pregnancy or abortion”

Several studies have recorded a higher success rate in the use of Cabergoline to decrease serum prolactin level over bromocriptine. The secretion of prolactin by the anterior pituitary is mainly under hypothalamic inhibitory control, likely exerted through release of dopamine by tuberoinfundibular neurons. Cabergoline is a long-acting dopamine receptor agonist with a high affinity for D2 receptors.

semen quality pic

Results of in vitro studies as published by FDA demonstrate that cabergoline exerts a direct inhibitory effect on the secretion of prolactin by rat pituitary lactotrophs.Cabergoline decreased serum prolactin levels in reserpinized rats. Receptor-binding studies indicate that cabergoline has low affinity for dopamine D1, α1- and α2-adrenergic,and 5-HT1- and 5-HT2-serotonin receptors.

The prolactin-lowering efficacy of DOSTINEX was demonstrated in hyperprolactinemic women in two randomized, double-blind, comparative studies, one with placebo and the other with bromocriptine. In the placebo-controlled study (placebon=20; cabergoline n=168), DOSTINEX produced a dose-related decrease in serumprolactin levels with prolactin normalized after 4 weeks of treatment in 29%, 76%, 74%and 95% of the patients receiving 0.125, 0.5, 0.75, and 1.0 mg twice weekly respectively.In the 8-week, double-blind period of the comparative trial with bromocriptine(cabergoline n=223; bromocriptine n=236 in the intent-to-treat analysis), prolactin was normalized in 77% of the patients treated with DOSTINEX at 0.5 mg twice weekly compared with 59% of those treated with bromocriptine at 2.5 mg twice daily.Restoration of menses occurred in 77% of the women treated with DOSTINEX,compared with 70% of those treated with bromocriptine. Among patients with galactorrhea, this symptom disappeared in 73% of those treated with DOSTINEX compared with 56% of those treated with bromocriptine. Pharmacokinetics Absorption: Following single oral doses of 0.5 mg to 1.5 mg given to 12 healthy adult volunteers, mean peak plasma levels of 30 to 70, some serious side effects have occurred during the use of bromocriptine to stop milk flow after pregnancy or abortion.

These side effects have included strokes, seizures (convulsions), and heart attacks. Some deaths have also occurred. You should discuss with your doctor the good that this medicine will do as well as the risks of using it.

More common effects are;

  • Dizziness or lightheadedness, especially when getting up from a lying or sitting position

  • nausea

    Less common—reported more often in patients with Parkinson’s disease

  • Confusion

  • hallucinations (seeing, hearing, or feeling things that are not there)

    uncontrolled movements of the body, such as the face, tongue, arms, hands, head, and upper body.

Rare—reported more often in patients taking large doses

  • Abdominal or stomach pain (continuing or severe)

  • increased frequency of urination

  • loss of appetite (continuing)

  • lower back pain

  • runny nose (continuing)

  • weakness

  • Rare

  • Black, tarry stools

  • bloody vomit

  • chest pain (severe)

  • convulsions (seizures)

  • fainting

  • fast heartbeat

  • headache (unusual)

  • increased sweating

  • nausea and vomiting (continuing or severe)

  • nervousness

  • shortness of breath (unexplained)

  • vision changes (such as blurred

  • vision or temporary blindness)

    weakness (sudden)

  • Severity: Minor

Some of the side effects that can occur with bromocriptine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

  • Less commoncommon

  • Constipation

  • diarrhea

  • drowsiness or tiredness

  • dry mouth

  • leg cramps at night

  • loss of appetite

  • mental depression

  • stomach pain

  • stuffy nose

  • tingling or pain in the fingers and toes when exposed to cold

  • vomiting

Some side effects may be more likely to occur in patients who are taking bromocriptine for Parkinson’s disease, acromegaly, or pituitary tumors since they may be taking larger dose.


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